P nervous system development 4.2e-17 1.9e-12 P multicellular organismal development 8.2e-13 1.8e-08 P system development 4.4e-12 5e-08 P neurogenesis 4.6e-12 5e-08 P generation of neurons 6e-12 5.3e-08 P neuron differentiation 2e-11 1.5e-07 P central nervous system development 1.2e-10 7.4e-07 P embryonic development 3.3e-09 1.8e-05 P developmental process 5.5e-09 2.7e-05 P regionalization 1.5e-08 6.4e-05 P regulation of gene expression 1.8e-08 7.4e-05 P regulation of transcription 2.6e-08 9e-05 P pattern specification process 2.6e-08 9e-05 P brain development 5.7e-08 0.00018 P anatomical structure morphogenesis 9.5e-08 0.00028 P embryonic morphogenesis 1.7e-07 0.00048 P neuron development 3e-07 0.00078 P transcription 3.4e-07 0.00081 P cell morphogenesis involved in neuron differentiation 3.5e-07 0.00081 P organ development 5.4e-07 0.0012 P anterior/posterior pattern formation 5.5e-07 0.0012 P forebrain development 9.9e-07 0.0019 P regulation of cellular biosynthetic process 9.5e-07 0.0019 P regulation of biosynthetic process 1.3e-06 0.0024 P cell morphogenesis involved in differentiation 1.5e-06 0.0026 P sensory organ development 1.9e-06 0.0032 P chordate embryonic development 2.2e-06 0.0036 P cell differentiation 2.5e-06 0.004 P embryonic development ending in birth or egg hatching 2.7e-06 0.0041 P cell fate commitment 3.1e-06 0.0046 P regulation of nervous system development 3.6e-06 0.0051 P regulation of macromolecule biosynthetic process 3.8e-06 0.0053 P regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 5.6e-06 0.0074 P axonogenesis 5.8e-06 0.0074 P organ morphogenesis 5.9e-06 0.0074 P regulation of neurogenesis 6.4e-06 0.0078 P homophilic cell adhesion 7.5e-06 0.0089 P neuron projection development 9e-06 0.01 P regulation of transcription from RNA polymerase II promoter 1.2e-05 0.013 P cell development 1.2e-05 0.013 P regulation of neuron differentiation 1.4e-05 0.015 P transmission of nerve impulse 1.7e-05 0.018 P neuron projection morphogenesis 2e-05 0.021 P ear development 2.1e-05 0.021 P Wnt receptor signaling pathway 2.2e-05 0.022 P skeletal system development 2.4e-05 0.023 P cellular macromolecule biosynthetic process 2.9e-05 0.027 P negative regulation of transcription from RNA polymerase II promoter 3.7e-05 0.034 P cell fate specification 3.8e-05 0.034 P gene expression 5.2e-05 0.045 P macromolecule biosynthetic process 6.3e-05 0.054 P limb morphogenesis 6.7e-05 0.056 P appendage morphogenesis 6.7e-05 0.056 P regulation of Wnt receptor signaling pathway 8.1e-05 0.066 P cartilage development 0.00011 0.085 P cellular developmental process 0.00011 0.085 P appendage development 0.00011 0.087 P limb development 0.00011 0.087 P embryonic skeletal system development 0.00012 0.088 P inner ear development 0.00012 0.088 P synaptic transmission 0.00013 0.096 P regulation of transcription, DNA-dependent 0.00016 0.12 P biosynthetic process 0.00017 0.12 P transcription from RNA polymerase II promoter 0.00018 0.12 P embryonic appendage morphogenesis 0.00021 0.14 P embryonic limb morphogenesis 0.00021 0.14 P embryonic organ development 0.00023 0.15 P ear morphogenesis 0.00026 0.17 P cellular biosynthetic process 0.00027 0.17 P axon guidance 0.00028 0.18 P neuron fate commitment 0.00032 0.2 P urogenital system development 0.00035 0.21 P skeletal system morphogenesis 0.00043 0.26 P positive regulation of transcription from RNA polymerase II promoter 0.0005 0.29 P mesoderm morphogenesis 0.00055 0.32 P kidney development 0.00059 0.34 P cell differentiation in spinal cord 0.00059 0.34 P regulation of Wnt receptor signaling pathway through beta-catenin 0.00062 0.35 P telencephalon development 0.00063 0.35 P transcription, DNA-dependent 0.00069 0.38 P spinal cord development 0.00075 0.4 P mesenchymal cell differentiation 0.00074 0.4 P mesoderm formation 0.0008 0.42 P inner ear morphogenesis 0.00084 0.44 P positive regulation of transcription, DNA-dependent 0.0009 0.47 P positive regulation of RNA metabolic process 0.001 0.53 P Wnt receptor signaling pathway through beta-catenin 0.0011 0.54 P regulation of RNA metabolic process 0.0011 0.55 P morphogenesis of a branching structure 0.0011 0.55 P neuron fate specification 0.0012 0.58 P ureteric bud development 0.0013 0.59 P branching morphogenesis of a tube 0.0012 0.59 P embryonic organ morphogenesis 0.0012 0.59 P mesoderm development 0.0013 0.62 P renal system development 0.0014 0.65 P positive regulation of transcription 0.0014 0.65 P ventral spinal cord development 0.0014 0.65 P negative regulation of transcription, DNA-dependent 0.0015 0.66 P heart development 0.0015 0.67 P negative regulation of transcription 0.0018 0.79 P growth 0.0018 0.79 P endocrine system development 0.0021 0.92 P glial cell differentiation 0.0041 1 P branching involved in ureteric bud morphogenesis 0.0026 1 P eye morphogenesis 0.0058 1 P molting cycle process 0.0098 1 P hair cycle process 0.0098 1 P response to estradiol stimulus 0.0078 1 P response to estrogen stimulus 0.0074 1 P embryonic skeletal system morphogenesis 0.0028 1 P regulation of growth 0.004 1 P retina morphogenesis in camera-type eye 0.01 1 P ossification 0.0031 1 P spinal cord motor neuron differentiation 0.0072 1 P regulation of cell development 0.0077 1 P regulation of cell proliferation 0.0082 1 P eye development 0.0028 1 P BMP signaling pathway 0.0025 1 P cellular response to vitamin 0.0039 1 P diencephalon development 0.0029 1 P cardiac chamber morphogenesis 0.0051 1 P phosphoinositide phosphorylation 0.0047 1 P heart morphogenesis 0.0039 1 P mesodermal cell fate commitment 0.01 1 P palate development 0.0026 1 P segmentation 0.0088 1 P negative regulation of Wnt receptor signaling pathway through beta-catenin 0.0071 1 P cell projection morphogenesis 0.0057 1 P smooth muscle contraction 0.01 1 P smoothened signaling pathway 0.0067 1 P hair follicle development 0.0098 1 P learning or memory 0.0025 1 P cellular response to vitamin A 0.0026 1 P cellular response to retinoic acid 0.0026 1 P lipid phosphorylation 0.0067 1 P hindbrain development 0.0034 1 P gliogenesis 0.0096 1 P in utero embryonic development 0.0047 1 P cell fate determination 0.0095 1 P axis specification 0.0054 1 P regulation of cell differentiation 0.0029 1 P placenta development 0.0097 1 P mesenchymal cell proliferation 0.01 1 P cell part morphogenesis 0.0093 1 P respiratory system development 0.0049 1 P negative regulation of Wnt receptor signaling pathway 0.0039 1 P cell morphogenesis 0.0028 1 P dorsal/ventral pattern formation 0.01 1 P cell projection organization 0.0049 1 P response to retinoic acid 0.0036 1 P behavioral interaction between organisms 0.0081 1 P embryonic pattern specification 0.0083 1 P camera-type eye development 0.0036 1 P cellular component morphogenesis 0.0099 1 P small GTPase mediated signal transduction 0.0029 1 P mesodermal cell differentiation 0.0055 1 P response to nutrient 0.007 1 P regulation of nitrogen compound metabolic process 0.0044 1 P response to vitamin 0.0075 1 P mesenchymal cell development 0.0025 1 P positive regulation of macromolecule biosynthetic process 0.006 1 P limbic system development 0.0066 1 P tube morphogenesis 0.0031 1 P chondrocyte differentiation 0.0025 1 P camera-type eye morphogenesis 0.01 1 P respiratory tube development 0.0047 1 P lung development 0.0047 1 P response to vitamin A 0.0059 1 P cellular response to nutrient 0.01 1 P ureteric bud morphogenesis 0.0029 1 P embryonic digit morphogenesis 0.01 1 F metal ion binding 5.3e-09 4.2e-05 F cation binding 2.9e-08 0.00011 F binding 1.1e-05 0.028 F ion binding 4.7e-05 0.093 F protein binding 7.8e-05 0.12 F Ras guanyl-nucleotide exchange factor activity 0.0061 1 F small GTPase regulator activity 0.0033 1 F guanyl-nucleotide exchange factor activity 0.0027 1 F phosphotransferase activity, alcohol group as acceptor 0.0095 1 F calcium ion binding 0.0058 1 F GTPase regulator activity 0.0038 1 F nucleoside-triphosphatase regulator activity 0.0026 1 F kinase activity 0.0054 1 C intracellular 2e-10 8.8e-07 C intracellular part 2.5e-09 5.6e-06 C intracellular membrane-bounded organelle 1.5e-08 2.2e-05 C intracellular organelle 9.7e-07 0.0011 C cell part 6.2e-06 0.0048 C membrane-bounded organelle 6.5e-06 0.0048 C cell 9.6e-06 0.0062 C neuron projection 3.6e-05 0.02 C organelle 6.2e-05 0.031 C nucleus 0.00016 0.072 C cytoplasm 0.00031 0.13 C leading edge membrane 0.00054 0.2 C cell junction 0.0018 0.64 C Golgi apparatus 0.0024 0.76 C dendrite 0.0026 0.76 C cell leading edge 0.0028 0.77 C plasma membrane part 0.0033 0.83 C postsynaptic membrane 0.0033 0.83 C postsynaptic density 0.0036 0.85 C cytoplasmic vesicle 0.0044 0.98 C cytoplasmic part 0.0046 0.98 C ruffle membrane 0.0061 1 C integral to plasma membrane 0.009 1 C ruffle 0.0093 1 C cytoplasmic membrane-bounded vesicle 0.0097 1 C ionotropic glutamate receptor complex 0.0082 1 C proteinaceous extracellular matrix 0.006 1