P regulation of gene expression 1.5e-11 5.2e-07 P regulation of transcription 2e-10 2.2e-06 P transcription 2.2e-10 2.2e-06 P cellular macromolecule biosynthetic process 2.4e-10 2.2e-06 P regulation of macromolecule biosynthetic process 4.9e-10 3.5e-06 P macromolecule biosynthetic process 1.2e-09 6.9e-06 P gene expression 1.9e-09 9.8e-06 P regulation of biosynthetic process 2.8e-09 1.2e-05 P regulation of cellular biosynthetic process 3.5e-09 1.2e-05 P nervous system development 3.5e-09 1.2e-05 P transcription from RNA polymerase II promoter 4e-09 1.3e-05 P cellular biosynthetic process 1.2e-08 3.4e-05 P cellular metabolic process 1.3e-08 3.7e-05 P biosynthetic process 2.1e-08 5.3e-05 P regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 6.8e-08 0.00016 P neurogenesis 8.4e-08 0.00019 P regulation of transcription from RNA polymerase II promoter 9e-08 0.00019 P nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.3e-07 0.00023 P axonogenesis 1.2e-07 0.00023 P neuron differentiation 2.1e-07 0.00038 P generation of neurons 2.6e-07 0.00044 P transcription, DNA-dependent 2.9e-07 0.00047 P metabolic process 3e-07 0.00047 P cell morphogenesis involved in neuron differentiation 4.2e-07 0.00062 P RNA metabolic process 9.3e-07 0.0013 P multicellular organismal development 1e-06 0.0014 P regulation of transcription, DNA-dependent 1.8e-06 0.0023 P neuron projection development 2.9e-06 0.0037 P central nervous system development 4.4e-06 0.0054 P neuron projection morphogenesis 4.8e-06 0.0057 P negative regulation of transcription from RNA polymerase II promoter 5.7e-06 0.0066 P system development 1.4e-05 0.016 P neuron development 2e-05 0.022 P regulation of RNA metabolic process 2.6e-05 0.027 P positive regulation of macromolecule biosynthetic process 2.6e-05 0.027 P developmental process 3.4e-05 0.034 P positive regulation of RNA metabolic process 3.6e-05 0.035 P positive regulation of transcription 4e-05 0.037 P RNA biosynthetic process 4.3e-05 0.039 P embryonic development 5.8e-05 0.05 P positive regulation of transcription, DNA-dependent 5.9e-05 0.05 P axon guidance 5.8e-05 0.05 P embryonic development ending in birth or egg hatching 6.1e-05 0.051 P regulation of nitrogen compound metabolic process 7.2e-05 0.059 P cellular macromolecule metabolic process 9.6e-05 0.076 P chordate embryonic development 0.00011 0.082 P regulation of neuron differentiation 0.00015 0.12 P regulation of nervous system development 0.00018 0.13 P anterior/posterior pattern formation 0.0002 0.14 P regionalization 0.0002 0.14 P forebrain development 0.00021 0.14 P regulation of neurogenesis 0.00021 0.14 P negative regulation of transcription, DNA-dependent 0.00021 0.14 P skeletal system morphogenesis 0.00023 0.15 P cell morphogenesis involved in differentiation 0.00024 0.15 P pattern specification process 0.00023 0.15 P brain development 0.00024 0.15 P macromolecule metabolic process 0.00026 0.16 P negative regulation of transcription 0.00027 0.16 P positive regulation of transcription from RNA polymerase II promoter 0.00028 0.16 P embryonic skeletal system development 0.00036 0.21 P anatomical structure morphogenesis 0.00036 0.21 P cell part morphogenesis 0.00039 0.22 P posttranscriptional regulation of gene expression 0.00042 0.23 P regulation of metabolic process 0.00042 0.23 P spinal cord development 0.00043 0.23 P positive regulation of biosynthetic process 0.00051 0.27 P positive regulation of cellular biosynthetic process 0.00058 0.3 P palate development 0.00066 0.34 P cell development 0.00077 0.39 P primary metabolic process 0.00079 0.4 P cell projection organization 0.0011 0.54 P cell projection morphogenesis 0.0013 0.66 P regulation of axonogenesis 0.0014 0.67 P cell differentiation 0.0014 0.68 P heart development 0.0015 0.71 P neuron fate commitment 0.0016 0.74 P positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 0.0018 0.83 P positive regulation of axonogenesis 0.002 0.91 P regulation of growth 0.0022 0.98 P circadian rhythm 0.0076 1 P cardioblast differentiation 0.0045 1 P response to DNA damage stimulus 0.0077 1 P enzyme linked receptor protein signaling pathway 0.007 1 P covalent chromatin modification 0.0097 1 P appendage development 0.005 1 P transmission of nerve impulse 0.01 1 P cell differentiation in spinal cord 0.0057 1 P nerve development 0.0061 1 P embryonic skeletal system morphogenesis 0.0026 1 P histone modification 0.0086 1 P positive regulation of cell cycle arrest 0.0043 1 P cardiac chamber development 0.0073 1 P organ development 0.0065 1 P axon extension 0.0079 1 P regulation of cell cycle arrest 0.0028 1 P limb morphogenesis 0.0023 1 P limb development 0.005 1 P Golgi vesicle transport 0.01 1 P innervation 0.0098 1 P neuron apoptosis 0.0088 1 P negative regulation of RNA metabolic process 0.0096 1 P DNA damage response, signal transduction by p53 class mediator 0.0078 1 P organ morphogenesis 0.0089 1 P telencephalon development 0.0043 1 P cellular process 0.0046 1 P appendage morphogenesis 0.0023 1 P regulation of cellular metabolic process 0.0032 1 P skeletal system development 0.0035 1 P dorsal spinal cord development 0.0084 1 P embryonic appendage morphogenesis 0.0055 1 P embryonic morphogenesis 0.004 1 P cellular developmental process 0.0048 1 P cell cycle 0.01 1 P embryonic limb morphogenesis 0.0055 1 P mRNA processing 0.006 1 P pallium development 0.0065 1 P ephrin receptor signaling pathway 0.0024 1 P cerebral cortex development 0.01 1 P growth 0.0081 1 F binding 6.7e-12 4e-08 F protein binding 1.9e-10 5.7e-07 F metal ion binding 1.1e-07 0.00021 F cation binding 5.8e-07 0.00086 F purine nucleotide binding 4.1e-05 0.038 F nucleotide binding 4.5e-05 0.038 F enzyme binding 3.7e-05 0.038 F purine ribonucleotide binding 5.4e-05 0.04 F adenyl nucleotide binding 8.4e-05 0.05 F chromatin binding 8.1e-05 0.05 F ATP binding 0.00011 0.051 F adenyl ribonucleotide binding 0.0001 0.051 F ribonucleotide binding 0.00011 0.051 F zinc ion binding 0.00018 0.072 F ion binding 0.00018 0.072 F catalytic activity 0.00021 0.074 F phosphotransferase activity, alcohol group as acceptor 0.0002 0.074 F kinase activity 0.00053 0.17 F protein kinase activity 0.00078 0.24 F protein serine/threonine kinase activity 0.0011 0.32 F transition metal ion binding 0.0011 0.32 F transferase activity, transferring phosphorus-containing groups 0.0015 0.4 F small GTPase regulator activity 0.0016 0.4 F Ras guanyl-nucleotide exchange factor activity 0.0017 0.43 F guanyl-nucleotide exchange factor activity 0.0025 0.6 F nucleoside-triphosphatase regulator activity 0.0063 1 F hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0055 1 F GTP-dependent protein binding 0.0098 1 F receptor signaling protein serine/threonine kinase activity 0.0079 1 F GTPase regulator activity 0.007 1 F Rho guanyl-nucleotide exchange factor activity 0.0086 1 F hydrolase activity, acting on acid anhydrides 0.006 1 F pyrophosphatase activity 0.0059 1 F ubiquitin conjugating enzyme binding 0.0085 1 F cytoskeletal protein binding 0.0073 1 F phosphoprotein phosphatase activity 0.0073 1 F GTPase binding 0.0062 1 F transmembrane receptor protein kinase activity 0.01 1 C intracellular 4.1e-31 1.5e-27 C intracellular part 1.6e-30 2.9e-27 C intracellular membrane-bounded organelle 4.6e-27 5.8e-24 C intracellular organelle 6.6e-25 6.2e-22 C membrane-bounded organelle 1.8e-21 1.4e-18 C organelle 1.7e-20 1.1e-17 C nucleus 1.8e-17 9.8e-15 C cytoplasm 5.7e-13 2.7e-10 C intracellular organelle part 2.8e-12 1.2e-09 C organelle part 1.5e-11 5.2e-09 C nuclear part 1.5e-11 5.2e-09 C nucleoplasm 3.9e-11 1.2e-08 C cell part 1.1e-10 3.3e-08 C cell 4.4e-10 1.2e-07 C cytoplasmic part 4.8e-10 1.2e-07 C nuclear lumen 3.4e-08 8.1e-06 C intracellular organelle lumen 1.5e-07 3.3e-05 C cytosol 2.4e-07 5.1e-05 C organelle lumen 2.8e-07 5.5e-05 C membrane-enclosed lumen 4.1e-07 7.6e-05 C cell leading edge 0.0001 0.018 C nucleoplasm part 0.00014 0.024 C anchoring junction 0.0002 0.033 C adherens junction 0.0003 0.048 C ruffle 0.00044 0.067 C perinuclear region of cytoplasm 0.00064 0.093 C cell junction 0.0011 0.16 C microtubule cytoskeleton 0.0012 0.16 C neuron projection 0.0016 0.2 C Golgi apparatus 0.0016 0.21 C cell-cell adherens junction 0.0022 0.27 C cell body 0.0037 0.43 C focal adhesion 0.0038 0.43 C actin filament 0.0039 0.44 C centrosome 0.0044 0.47 C cell-substrate adherens junction 0.0047 0.49 C cell-substrate junction 0.0052 0.53 C cell-cell junction 0.0063 0.63 C cytoplasmic vesicle 0.0069 0.67 C microtubule organizing center 0.0074 0.69 C filopodium 0.009 0.82 C neuronal cell body 0.01 0.9